PAL System Thermal Mixer for Shaking and Heating of Well Plates

• Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
• US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
• This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
• We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

Gas Chromatography coupled with Triple Quadrupole Mass Spectrometry (GC/TQ) offers a robust and sensitive method for
detecting volatile PFAS. However, manual sample preparation could pose a bottleneck, impacting lab productivity. This study presents a robust and fully automated method using the PAL3 platform with GC/TQ for quantifying more than 30 volatile PFAS in FCMs, such as paper coffee cups. The automation approach minimizes human error, improving reliability
and reproducibility for routine analysis and safety assessments of PFAS in FCMs.

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond. 

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

• PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
• Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
• Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
• Deep Dive: Explore online SPE for PFAS analysis.

In this presentation we want to discuss an important development and a demand from analytical laboratories about the standardization and the automation of sample preparation procedures for food safety, environmental, the forensic or pharmaceutical analysis.

Presented by:
Hans-Joachim Huebschmann, PhD

This application note demonstrates the successful automation of two sample preparation workflows, Formic Acid (FA) and Beads method, for bacterial identification using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS).

A Robust Method for Comprehensive Metabolomic Profiling of Dried Blood Spots, Serum, and Plasma

PAL3 Thermal Mixer – Temperature controlled heating and
mixing for well plates to boost your sample prep efficiency.

Equip your PAL Systems for PFAS Analysis with Upgrade Kits and minimize PFAS Background.