uSPE Cartridge - GCB - 10 mg - 01-22A, 108 pcs, [GCB]

This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

• Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
• US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
• This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
• We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

This eBook explores the potential of uSPE to transform analytical workflows. It highlights the key benefits of uSPE, compares it with traditional techniques and examines its application across various industries. This resource provides a comprehensive guide for scientists and lab managers looking to optimize their sample preparation processes, achieve higher precision and embrace sustainable practices in analytical chemistry.

Forever chemicals, forever challenges?

The world of PFAS analysis is demanding, with tightening regulations and complex sample matrices pushing laboratories to their limits. This complimentary webinar series cuts through the noise, offering practical, expert-led guidance on how automated sample preparation can transform your workflows. Explore our webinars to learn how to boost sensitivity, ensure reproducibility, and tame the forever chemicals for good. We will touch on different sample workflows as well as spotlight different matrices, from food & food safety to environmental sample types.

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

• PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
• Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
• Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
• Deep Dive: Explore online SPE for PFAS analysis.

A Fully Automated Workflow for High-Throughput Analysis of Volatile PFAS in Food Contact Materials.

A Comparative Analysis of Sample Preparation Techniques for PFAS Analysis

See this detailed video of the uSPE workflow for the clean-up of raw pesticides extract. The PAL uSPE Cartridge is operated in scavenger mode eluting the pesticides in a clean extract. The matrix is kept on the sorbent material. The cleaned extract can be injected without waiting time online for LC/MS or GC/MS analysis. All samples are treated on the same time axis for highest reliability.

Equip your PAL Systems for PFAS Analysis with Upgrade Kits and minimize PFAS Background.

Methods in minutes

Chiew Mei Chong1, Hans-Joachim Hübschmann2

1 CTC Analytics Pte. Ltd., Singapore.
2 HANS Analytical Solutions, Osaka, Japan.