PAL System LC/MS setup for 250 µl Smart Syringes, Needle Length 51 mm, including 2-Channel Volumetric Pump, Wash Cup PEEK

This application note showcases a fully automated workflow for the precise quantification of 73 PFAS in seafood. Utilizing a PAL RTC autosampler and Agilent triple quadrupole LC/MS system (LC/TQ), the method automates calibration, QuEChERS extraction, and μSPE clean-up.

Herein, we describe the development of a new high-throughput approach based on the newly introduced SampleStream Platform for performing clone selection screening, enabling selection of clones that produce the highest amount and quality of the correctly assembled bispecific antibody.
 

The analysis of small molecules and lipids in blood offers insights into systemic physiological and pathological states. Accurate metabolite quantification is essential to detect metabolic alterations associated with health, nutrition anddisease status and therapeutic interventions, underpinning biomarker discovery and precision medicine. Achieving reliable and consistent metabolite quantification in complex biofluids such as blood serum and plasma requires standardized sample handling and analytical workflows.

The use of lipidomic analyses based on LC-mass spectrometry has become widespread due to its sensitivity and specificity which provides a broader picture of lipid profiles in biofluids. In this work, we combined an automated sample extraction and a two-dimensional liquid chromatography (2DxLC) system with HILIC-based class separation followed by an orthogonal reverse-phase chromatography with an untargeted SWATH-DIA workflow to accurately annotate phosphatidylcholines (PC), lysophosphatidylcholine (LPC) and etherphosphatidylcholines (PC O-) in human plasma samples.

If you're looking for ways to improve your analysis of complex matrices or trace contaminants, these expert-led sessions are for you

Join us for a deep dive into recent research comparing SPME Fiber and SPME Arrow for ultra-trace volatile PFAS. Learn directly from the author which geometry and extraction mode provides the best performance.

To support the scientific community and advance PFAS analysis we are proud to offer a webinar on this topic.

Key topics:

• PFAS Fundamentals: Learn about the chemistry and significance of PFAS compounds.
• Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.
• Automated LC/MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC/MS to optimize sample preparation and injection.
• Deep Dive: Explore online SPE for PFAS analysis.

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

This compendium on instrumental sample preparation showcases the many proven solutions of automated sample preparation workflows for food, environmental, pharma, life science analysis, and beyond. 

Discover how to automate your PFAS Analysis

Equip your PAL Systems for PFAS Analysis with Upgrade Kits and minimize PFAS Background.

Three new LC-MS Tools, all equipped with Smart Syringes.

for PAL LC-Systems