This Application Note summarizes a study by Williams et al. (2025) that performs a comprehensive comparison of two Solid Phase Microextraction (SPME) geometries: the traditional SPME Fiber and the robust SPME Arrow. The study systematically evaluates the impact of SPME geometry and extraction mode (Headspace vs. Direct Immersion) on extraction efficiency. The results provide a clear, data-driven basis for method development, showing how SPME configurations can be optimized for the specific physicochemical properties of different PFAS analytes.

A Fully Automated Workflow for High-Throughput Analysis of Volatile PFAS in Food Contact Materials.

This poster presents two use cases for streamlined lipid profiling in plasma using automated Micro Solid Phase Extraction (μSPE). Where the workflows on NIST (SRM 1950) plasma samples was tested, with spiked internal standard (Ultimate SPLASH ONE) and optimized the extraction and elution parameters. Briefly, it focused on two cartridge sorbent types Mixed-Mode Cation Exchange (MCX) and C18 (CEC) and showcased their usage.

• Widespread use and persistence of PFAS has led to ubiquitous detection in water, soil, air, and living organisms.
• US EPA Method 1633 is intended for analysis of PFAS in aqueous, solid and tissue samples using LCMS/ MS at part-per-trillion concentrations.
• This method involves significant sample preparation and purification steps prior to instrumental analysis, leading to bottlenecks in sample processing.
• We have developed a fully automated, online μSPE-LC-MS/MS workflow based on a customized LC TriPlus RSH SMART Advanced system for high-throughput analysis of PFAS in environmental samples following EPA Method 1633 guidelines

Forever chemicals, forever challenges?

The world of PFAS analysis is demanding, with tightening regulations and complex sample matrices pushing laboratories to their limits. This complimentary webinar series cuts through the noise, offering practical, expert-led guidance on how automated sample preparation can transform your workflows. Explore our webinars to learn how to boost sensitivity, ensure reproducibility, and tame the forever chemicals for good. We will touch on different sample workflows as well as spotlight different matrices, from food & food safety to environmental sample types.

We will discuss common pitfalls, things to look out for, especially in the pre-analytical phase, extractions (from monophasic to biphasic extractions) and talk about the integration of different -omics.

At a glance:

• Challenges in metabolomics sample preparation and studies
• Significance of standardized protocols and automation
• Integration of metabolomics and proteomics workflows

Automated, Green, and Efficient
A Compendium on Micromethods in Analytical Sample Preparation

Discover robust, precise, and reliable analytical methods while following the principles of Green Analytical Chemistry in various fields such as Food & Food Safety, Environmental, Clinical, Life Science, and Chemical.

This eBook explores the potential of uSPE to transform analytical workflows. It highlights the key benefits of uSPE, compares it with traditional techniques and examines its application across various industries. This resource provides a comprehensive guide for scientists and lab managers looking to optimize their sample preparation processes, achieve higher precision and embrace sustainable practices in analytical chemistry.

Discover how to automate your PFAS Analysis

Easily switch form SPME Fiber to SPME Arrow without changing the Tool.

Modernize your Laboratory Transform your Research

PAL3 Thermal Mixer – Temperature controlled heating and
mixing for well plates to boost your sample prep efficiency.

Chiew Mei Chong1, Hans-Joachim Hübschmann2

1 CTC Analytics Pte. Ltd., Singapore.
2 HANS Analytical Solutions, Osaka, Japan.

Maintaining and preparing your syringe are two of the most important aspects to guarantee your PAL System can provide reliable results. This Article shows you the tips and tricks to adequately preapre your syringe for use as well as to prolong the lifetime.

General Information for PAL SPME Fibers

Edition 4

Edition 11.1

Our products convince through quality and innovation. We implement demanding development projects. In doing so, we maintain active cooperation with technology partners, suppliers and universities. We align our company processes with the ISO standard EN 13485.

CTC Analytics supports the goal of ending violence, human rights violations and environmental devastation in the Covered Countries. We are committed to complying with all requirements applicable to our Company under the Conflict Minerals Rule. CTC Analytics complies with US - Dodd-Frank Act known as the ''Conflict Minerals Rule".

The performance of SPME Fibers is an essential aspect of an analytical method. This study shows the comparison of three different SPME Fibers of a conventional brand  and the new PAL SPME Fibers.

Sustainability is a key part of our strategy/values -this already since the foundation of the company in 1984. It is deeply anchored in our business activities and investment decision-making. Our commitment goes far beyond compliance with legal requirements. We are convinced that a careful use of resources is key to our long-term success. Consequently, we live a very sustainable culture in our company, which shapes the decisions and behavior of our employees.